The Life of Langston Hughes and his use of Religion, Rite of Passage, Research Paper

The Life of Langston Hughes and his use of Religion, Rite of Passage, and Family in his short stories - Research Paper Example Because of racism, he provided a remarkable authority on the black all through the US in the era referred to as the Harlem Renaissance. He was among the most inexhaustible and most recognized black poets of the renaissance. He was among the few that broke the barriers that several artists had achieved before. His articulation not only endorsed African American civilization, but also endeavoured to bring notice the predicament of African American anguishing from injustice and oppression (Baraceros, 118). In his book essay, salvation Hughes retells an experience concerning religion. He narrates that, he was salvaged from sin, when he was turning thirteen, but was not truly saved. This experience affected how he dealt with situations in religion in the future. The start of the story has a tone that excites the reader and makes them inquisitive and hopeful. However, eventually the tone disappoints the readers making them culpable and non-believers. A restoration that gains thrust for day s is a climatic flat line for Langston leaving him an agnostic. His aunt tells a curious Langston that, grand things will occur at revitalization, at the cathedral of his Auntie Reed. He is told that he will experience an incredible feeling within and will be delivered. Had this before from others and does not deem it right to question his aunt. He is hopeful that, at the revival, Jesus will call children. The children are called up, and he takes a pew on the bench waiting for Jesus to reveal himself. He waits for a long time, but Jesus never appears. There are only two children left on the bench and the other child decides he will meet Jesus to end things but a hopeful Langston waits (Baraceros, 234). Langston is disillusioned that Jesus did not come to assist him when all eyes were focused on him. This made to lie to his aunt that he had seen when he cried that night out of disappointment. He has heard several people older people discuss what happens when one goes to Jesus. This m ade to be hopeful, curios and excited, but at the end, the complete opposite is the outcome. These two extremes lead to Langston to be a non-believer. Another Hughes’ significant story is â€Å"Thank you Ma’m.† This story is about an elderly woman walking alone in the dark when suddenly a boy attempts to grab her purse. Nonetheless, during the effort, he loses his steadiness and slides on the pavement and the annoyed woman picks him up and teaches him a thorough lesson. She takes the boy to her home so that he could wash his face and have a pleasant e meal, before she hands him some money to buy blue suede shoes he has always wished for a long time. This story appears to be written around the 1930s when racism was a prodigious topic in the southern states, during those times numerous African Americans had problems looking for a job. During this period, many blacks had to fight for their freedom. From Rogers' perception, children went through a rough period as we ll during that era. He is dirty and frail and a street rogue. He depicts the life of many children of that time. Mrs Washington Jones, the elderly woman sympathises with Roger even though he tries to steal from her. She depicts a different side of the poor neighbourhood; a sturdy woman who depicts kindness to a stranger one would not expect her to be bothered. Many children in poor neighbourhoods had little to go home to,

Risk Factors for Colon Cancer Research Paper Example | Topics and Well Written Essays - 1000 words

Risk Factors for Colon Cancer - Research Paper Example In most cases a combination of inhibitors is necessary to maximize the efficacy of the drug treatment. The possible side-effects associated with these drugs is still under investigation. Thus at present the prognosis for colon cancer associated with obesity has been found to be poor, however the combinational use of inhibitors could change the current prognosis. Keywords: colon cancer, obesity, insulin, adipokines According to recent surveys colon cancer is the third most commonly occurring cancer in males and second in the case of females associated with a mortality rate of 608,700 (Chen, 2012). About 1.2 million people are diagnosed with this type of cancer every year (Whitlock, Gill, Birch, & Karmali, 2012). There are many causative factors involved in the pathogenesis of colon cancer which include environmental factors such as a high-fat/ low-fiber dietary intake, genetic factors such as inherited or cellular genetic mutations, life style changes such as smoking, physical inactiv ity and obesity (Chen, 2012; Ma, Yang, Wang, Zhang, Shi, Zou, & Qin, 2013). Studies have shown a strong link between obesity and the incidence of colon cancer. Obesity, which is measured as the body mass index, is on a rise over the past few decades all over the world. The World Health Organization estimates show that about 10% of the world population is clinically obese (Whitlock, Gill, Birch, & Karmali, 2012). Obesity is associated with an increased risk of type II diabetes, hypertension, hyperlipidemia and heart disease. These conditions increase the serum levels of cancer risk factors such as insulin, insulin-like growth-factor 1 (IGF-1), leptin, interleukin-6, 17 (IL-6, IL-17), tumor necrosis factor alpha (TNF-alpha) and decreases serum levels of adiponectin which is considered to indirectly protect against cancer (Chen, 2012; Van Kruijsdijk, van der Wall, & Visseren, 2009). The role of insulin and IGF-1 in the carcinogenic process has been supported by clinical studies. These factors in turn activate multiple signal pathways which can induce tumor growth. For example increased secretion of insulin and IGF-1 stimulate cancer growth by binding to their specific receptors and activate pathways that inhibit apoptosis and stimulate cell proliferation. IGF-1 stimulates the proliferation of cells by activating the signal pathways phosphatidylinositol 3-kinase and Ras/Raf mitogen activated protein kinase systems and signal transducer and activator of transcription 3 pathways (STAT 3). IGF-1 is also involved in cell migration and invasion which favors cancer progression and metastasis (Chen, 2012; Van Kruijsdijk, van der Wall, & Visseren, 2009; Frezza, Wachtel, & Chiriva-Internati, 2006). Adipose tissue dysfunction in obese individuals plays a major role in promoting carcinogenesis by affecting important biochemical mechanisms such as insulin resistance, and production of adipokines and cytokines involved in inflammation. An increased leptin level which is secret ed by the adipocytes in obese individuals is associated with the growth and proliferation of cancer cells. The leptin hormone is known to promote mitogenesis, angiogenesis, and inflammation and inhibit apoptosis (Van Kruijsdijk, van der Wall, & Visseren, 2009; Frezza, Wachtel, & Chiriva-Internati, 2006). Obesity is also associated with decreased levels of adipone